Canadian researchers use tropical fish to unlock the future of tooth regrowth and brain healing
MANITOBA: Can fish help humans regrow teeth? Scientists at the University of Manitoba think so—and they're diving deep to prove it.
In a promising leap for regenerative medicine, researchers in Canada are studying the regenerative powers of tropical fish to one day help humans regrow teeth and repair brain injuries.
Located in the Rady Faculty of Health Sciences, the high-tech facility houses over 2,000 zebrafish and 250 Mexican tetra fish, both known for their extraordinary regenerative abilities.
A natural blueprint for regrowth
“About 70% of fish genes are the same as human genes,” says Dr. Benjamin Lindsey, assistant professor of human anatomy and cell science. His research focuses on zebrafish, a species capable of regrowing neural tissue after spinal or brain injuries.
“These fish have powerful neural stem cells. If we can unlock how their tissue regenerates after trauma, it could transform treatments for Parkinson’s, Alzheimer’s, and spinal cord injuries in humans,” Lindsey added.
Uncovering the genetics of facial development
Working alongside him is Dr. Devi Atukorallaya, an associate professor of oral biology and the only researcher in Canada using Mexican tetras for biomedical research.
Her work examines craniofacial and dental development by studying transparent fish embryos. These embryos offer a rare window into the early formation of bones, teeth, and organs, helping scientists understand birth defects like cleft palate.
What makes Mexican tetras particularly interesting is their dual evolution—surface-dwelling fish with eyes, and cave-dwelling fish that are blind. This contrast provides insights into how genetics and environment shape development. Atukorallaya has also pioneered studies on fetal alcohol spectrum disorder by exposing fish eggs to alcohol and observing anomalies in tooth and tastebud formation.
Why zebrafish and Mexican tetras?
- Zebrafish: Renowned for their tissue regeneration, especially in brain and spinal cells.
- Mexican tetras: A genetic treasure with translucent embryos and dual-evolution traits, ideal for craniofacial and dental research.
The future of regenerative medicine
The new facility, located in the Chown Building’s basement, is equipped with automated systems that regulate water quality and habitat conditions for the fish. The University hopes that this investment will pave the way for gene-based therapies that could one day help humans regrow lost teeth or heal nervous system injuries without invasive procedures.
As research evolves, these tropical fish may hold the key to a future where tooth loss and neurological damage are no longer permanent—replaced instead by self-healing biology, inspired by nature.
CLICK HERE TO FOLLOW the official Dental News Pakistan WhatsApp Channel for real-time updates, expert insights, and exclusive stories that matter to every dental professional.