Apple peel extract could fight periodontal disease, study finds
Apple peel extract may offer a natural way to prevent and treat gum disease, according to a new study. Researchers from São Paulo State University have discovered that morin, a plant-derived compound found in apple peel, guava leaves, fig peel, certain teas, and almonds, shows strong antimicrobial, anti-inflammatory, and antioxidant effects when tested against bacteria that cause periodontal disease.
How morin works against gum disease
The researchers tested morin against a multi-species bacterial biofilm designed to mimic gum disease in patients. The compound was delivered in a powdered form created using a process similar to making powdered milk.
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Study author Luciana Solera Sales explained: “We started developing these systems in the form of tablets, films, and microparticles. But until then, they were too large and unfeasible for oral use. That’s why I developed this format, which looks like powdered milk. I prepared a solution containing sodium alginate and gellan gum to encapsulate morin in a controlled-release system, which is already widely used for drugs but isn’t yet widely used in dentistry.”
Potential benefits for oral care
Supervisor Fernanda Lourenção Brighenti said this innovation could lead to new oral hygiene products, especially for those who struggle with manual brushing:
“The idea is to provide a platform that acts as an adjunct and can be useful, for example, for people with reduced motor skills who are unable to brush their teeth properly, such as older adults and patients with special needs.”
Morin was chosen because it is inexpensive, naturally available, and widely present in fruits. However, simply eating apples or other fruits is not enough — the compound needs to be processed for therapeutic use.
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Sales added:
“The idea is to take advantage of this natural compound, its benefits, and its advantages, and transform it so that it can be used to prevent and treat tooth decay and periodontal disease.”
Next steps in research
The team plans to continue testing in animal models before moving on to human clinical trials. Future research will explore whether morin-based treatments can maintain the oral microbiome and reduce tooth staining while effectively managing gum disease.
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